1. Cancer therapy and cachexia

Thakir TM, et al., Cancer therapy and cachexia. J Clin Invest. 2025 Aug 1;135(15):e191934. doi: 10.1172/JCI191934. PMID: 40759570; PMCID: PMC12321403.

2.Unravelling cysteine-deficiency-associated rapid weight loss

Varghese A, et al., Unravelling cysteine-deficiency-associated rapid weight loss. Nature. 2025 Jul;643(8072):776-784. doi: 10.1038/s41586-025-08996-y.

3. Clues to why the weight-loss condition cachexia arises when cancer occurs

Haase K, Jamal-Hanjani M. Clues to why the weight-loss condition cachexia arises when cancer occurs. Nature. 2025 Oct;646(8086):805-806. doi: 10.1038/d41586-025-02594-8. PMID: 41062752.

4. Metabolic Reprogramming in Cancer Cachexia

Maria Ibrahim, Maria Gomez-Jenkins, Eileen White. 2026. Metabolic Reprogramming in Cancer Cachexia. Annual Review Cancer Biology. 10:77-92. https://doi.org/10.1146/annurev-cancerbio-070924-011243

5. Implementation and Feasibility of a Multidisciplinary Endocrine-Led Outpatient Clinic for Cancer Cachexia and Other Forms of Unintentional Weight Loss: A Real-World Observational Study

Murthy, A.; Simons, M.; Jablonski, A.; Hurd, M.; Shukla, A.; Goncalves, M.D. Implementation and Feasibility of a Multidisciplinary Endocrine-Led Outpatient Clinic for Cancer Cachexia and Other Forms of Unintentional Weight Loss: A Real-World Observational Study. Cancers March 2026, 18, 946. https://doi.org/10.3390/cancers18060946

6. Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms

Petsakou, A., Filine, E., Li, M. et al. Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms. Nat Commun 17, 3553 March (2026). https://doi.org/10.1038/s41467-026-70074-2

7. Leveraging Multiomic Signatures to Predict Body Composition

Lakshmi S Devarakonda S, Hughes DA, Rodriguez C, Goncalves MD, Heymsfield SB. Leveraging Multiomic Signatures to Predict Body Composition. Adv Nutr. 2026 May;17(5):100626. doi: 10.1016/j.advnut.2026.100626. Epub 2026 Apr 3. PMID: 41936876; PMCID: PMC13146523.

8. Separating food intake-dependent and -independent effects in cancer cachexia

Liang, Y., Y.-Y. Kwon, and S. Hui, Separating food intake-dependent and independent effects in cancer cachexia. iScience, May 2026. 29(5): p. 115525. doi: https://doi.org/10.1016/j.isci.2026.115525

9. Reduced Muscle Loss in Patients With NSCLC Taking Fibrates: Findings From a Retrospective Observational Study

Elahjji R, Blow T, Grover R, Hurd MA, Dunne RF, Caan BJ, Cespedes Feliciano EM, Plodkowski AJ, Flory JH, Goncalves MD. Reduced Muscle Loss in Patients With NSCLC Taking Fibrates: Findings From a Retrospective Observational Study. J Cachexia Sarcopenia Muscle. 2025 Aug;16(4):e70016. doi: 10.1002/jcsm.70016. PMID: 40833872; PMCID: PMC12366630.

9. The Power of Drosophila in Modeling Cancer Cachexia

ADDCheng, C. et al. (2025). The Power of Drosophila in Modeling Cancer Cachexia. In: Deng, WM., Gonzaléz, C. (eds) The Drosophila Model in Cancer. Advances in Experimental Medicine and Biology, vol 1482. Springer, Cham. https://doi.org/10.1007/978-3-031-97035-1_5

1. Unraveling cysteine deficiency-associated rapid weight loss.

Varghese A, Gusarov I, Gamallo-Lana B, Dolgonos D, Mankan Y, Shamovsky I, Phan M, Jones R, Gomez-Jenkins M, White E, Wang R, Jones D, Papagiannakopoulos T, Pacold ME, Mar AC, Littman DR, Nudler E. Unraveling cysteine deficiency-associated rapid weight loss. bioRxiv [Preprint]. 2024 Jul 31:2024.07.30.605703. doi: 10.1101/2024.07.30.605703. PMID: 39131293; PMCID: PMC11312522. 

2.Separating anorexia -dependent and -independent effects in cancer cachexia

Liang, Y., Kwon, YY., Hui, S. Separating anorexia -dependent and -independent effects in cancer cachexia. bioRXiv[pre-print]2025.04.24.650538;doi:https://doi.org/10.1

3. Sustained Glucose Turnover Flux Distinguishes Cancer Cachexia from Nutrient Limitation

Kwon YY, Liang Y, Gomez-Jenkins M, Ahmed M, Jiang G, Hsiang J, Lewis DY, Janowitz T, Goncalves MD, White E, Hui S. Sustained Glucose Turnover Flux Distinguishes Cancer Cachexia from Nutrient Limitation. bioRxiv [Preprint]. 2025 May 20:2025.05.15.654370. doi: 10.1101/2025.05.15.654370. PMID: 40475657; PMCID: PMC12139815.

4. A health-system-scale, episode-resolved multimodal atlas of cancer cachexia 

Venise Jan Castillon, Amy Xie, Sonia Boscenco, Ethan Tse, Neil Ruthen, Jamie Wang, Ziad El Bakouny, Michele Waters, Chenlian Fu, Christopher Fong, Urvi A Shah, A Ari Hakimi, Justin Jee, Eileen White, Tobias Janowitz, Marcus Goncalves, Ed Reznik. A health-system-scale, episode-resolved multimodal atlas of cancer cachexia; medRxiv 2025.09.29.25336906; doi: https://doi.org/10.1101/2025.09.29.25336906 

1. Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice

Liu, Y., Dantas, E., Ferrer, M. et al. Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice. Nat Metab 7, 823–841 (2025).

2. Early identification of weight loss trajectories in advanced cancer and associations with survival

Fuller, S., et al., Early identification of weight loss trajectories in advanced cancer and associations with survival. J Natl Cancer Inst, 2025.

3. Call to Improve Coding of Cancer-Associated Cachexia

Goncalves, M.D., et al., Call to Improve Coding of Cancer-Associated Cachexia. JCO Oncol Pract, 2025: p. OP2400781.

4. Cancer-Associated Cachexia: Bridging Clinical Findings with Mechanistic Insights in Human Studies

Koh, K., et al., Cancer-Associated Cachexia: Bridging Clinical Findings with Mechanistic Insights in Human Studies. Cancer Discov, 2025: p. OF1-OF26.

5. Reproducibility of Plasma Metabolome over 1 Year in a Population-Based Cohort of Black Breast Cancer Survivors

Qin, B., et al., Reproducibility of Plasma Metabolome Over 1 Year in a Population-based Cohort of Black Breast Cancer Survivors. Cancer Epidemiol Biomarkers Prev, 2025.

1. EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

Mucciolo, G., Araos Henríquez, J., Jihad, M., Pinto Teles, S., Manansala, J. S., Li, W. ,…, Biffi, G. (2024). EGFR-activated myofibroblasts promote metastasis of pancreatic cancer. Cancer Cell, 42(1), 101–118.e11. https://doi.org/10.1016/j.ccell.2023.12.002

2. Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice

3. Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer

4. IL-6 promotes tumor growth through immune evasion but is dispensable for cachexia

5. Embracing cancer complexity: Hallmarks of systemic disease

6. Ponsegromab for the Treatment of Cancer Cachexia

7. Embracing cancer complexity: Hallmarks of systemic disease 

8. Why do patients with cancer die?

9. Mortality burden of pre‐treatment weight loss in patients with non‐small‐cell lung cancer: A systematic literature review and meta‐analysis

10. Area postrema neurons mediate interleukin-6 function in cancer cachexia

11. Mechanistic characterization of a Drosophila model of paraneoplastic nephrotic syndrome

1.Body composition and lung cancer-associated cachexia in TRACERx.

Al-Sawaf O, Weiss J, Skrzypski M, Lam JM, Karasaki T, Zambrana F, Kidd AC, Frankell AM, Watkins TBK, Martínez-Ruiz C, Puttick C, Black JRM, Huebner A, Bakir MA, Sokač M, Collins S, Veeriah S, Magno N, Naceur-Lombardelli C, Prymas P, Toncheva A, Ward S, Jayanth N, Salgado R, Bridge CP, Christiani DC, Mak RH, Bay C, Rosenthal M, Sattar N, Welsh P, Liu Y, Perrimon N, Popuri K, Beg MF, McGranahan N, Hackshaw A, Breen DM, O’Rahilly S, Birkbak NJ, Aerts HJWL; TRACERx Consortium; Jamal-Hanjani M, Swanton C. Body composition and lung cancer-associated cachexia in TRACERx. Nat Med. 2023 Apr;29(4):846-858. doi: 10.1038/s41591-023-02232-8. Epub 2023 Apr 12. PMID: 37045997; PMCID: PMC7614477.

2. Cachexia: A systemic consequence of progressive, unresolved disease.

Ferrer M, Anthony TG, Ayres JS, Biffi G, Brown JC, Caan BJ, Cespedes Feliciano EM, Coll AP, Dunne RF, Goncalves MD, Grethlein J, Heymsfield SB, Hui S, Jamal-Hanjani M, Lam JM, Lewis DY, McCandlish D, Mustian KM, O’Rahilly S, Perrimon N, White EP, Janowitz T. Cachexia: A systemic consequence of progressive, unresolved disease. Cell. 2023 Apr 27;186(9):1824-1845. doi: 10.1016/j.cell.2023.03.028. PMID: 37116469.

3. Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.

Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, Rubino R, Gao Q, Flint TR, Young L, Connell CM, Lukey MJ, Goncalves MD, White EP, Venkitaraman AR, Janowitz T. Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia. Cell Metab. 2023 Jul 11;35(7):1147-1162.e7. doi: 10.1016/j.cmet.2023.05.008. Epub 2023 Jun 12. PMID: 37311455.

4.REPTOR and CREBRF encode key regulators of muscle energy metabolism

Saavedra, P., Dumesic, P.A., Hu, Y. et al. REPTOR and CREBRF encode key regulators of muscle energy metabolism. Nat Commun 14, 4943 (2023). https://doi.org/10.1038/s41467-023-40595-1

1. Cancer cachexia: lessons from Drosophila

Liu Y, Saavedra P, Perrimon N. Cancer cachexia: lessons from Drosophila. Dis Model Mech. 2022 Mar 1;15(3):dmm049298. doi: 10.1242/dmm.049298. Epub 2022 Mar 23. PMID: 35319749; PMCID: PMC8961677.